Chinese scientists have discovered a key anti-aging metabolite

2022-07-26 0 By

The Year of the Tiger is here, and everyone is talking about the tiger. Today, let’s talk about the tiger’s food — deer.Antler velvet from deer is the only mammalian organ found to be able to fully regenerate.For many years, velvet antler has been used as medicine or as a dietary supplement, and people hope to gain anti-aging and disease-prevention ability from it, but the mechanism is not very clear.Chinese scientists have conducted molecular mapping at the metabolic level of a variety of deer antler cells, including stem cells, to find out what kind of life-active substance gives velvet antler the ability to regenerate, according to research published in Cell Discovery on Feb 1.”Our analysis included both antler antler stem cells and blastemates derived from amputated limbs of the ‘king of regeneration’ salamander, as well as young primate tissue and highly regenerative human stem cells.””After high-precision analysis of these cells, we hope to find out what is the difference in regenerative ability,” said Qu Jing, one of the paper’s corresponding authors and a researcher at the Institute of Zoology, Chinese Academy of Sciences.Are stem cells “less useful as they age” or “less useful as they evolve”?During the annual antler regeneration process, antler antler stem cells located in the periosteum of the antler can differentiate to produce complete antler organs including blood vessels, cartilage, bone, dermis and nerves.It can be seen that stem cells are the leading role in regeneration.”The regenerative and repair effects of stem cells are cross-species. Human adult stem cells can also regenerate and repair a variety of tissues and organs.”The problem, qu says, is that this ability declines with age.One clue scientists have identified is that both evolution and aging reduce the coveted ability to regenerate.Presumably, the same changes have occurred with aging and evolution.The team decided to learn from the regenerative process of lower animals in nature and from young stem cells with strong regenerative ability by comparing the rule that stem cells become more useless as they grow older with the rule that it is more difficult to regenerate as they evolve.”We chose the metabolic level for our analysis.”Qu Jing said that there had been genetic level, transcriptome level of analysis and research, although the metabolic level is more complex, more cumbersome, but the reflection of life is more direct, less confusing information.More importantly, evolutionarily conserved small molecule metabolites have no interspecies immune rejection.With the development of biotechnology, the means to capture and metabolize small molecules continue to improve.Tricarboxylic acid cycle metabolism, pentose phosphate metabolism, glycogen metabolism, polyamine metabolism, uracil metabolism, fatty acid metabolism…The road map of metabolic pathways has been rounded over the years.Within the framework of existing metabolic pathways, the team analyzed a large number of cells across species, ages, and tissues, and found that regenerative cells have their own “preferences” for metabolic pathways, with enrichment of polyamine metabolism, uracil metabolism, and fatty acid metabolism occurring more frequently.”We believe that these metabolic pathways are cross-species conserved and closely associated with regeneration, and may contain a code for regeneration.”Weiqi Zhang, one of the paper’s corresponding authors and a researcher at the Beijing Institute of Genomics, Chinese Academy of Sciences.At the same time, the research team combined the existing human stem cell aging research platform to screen for potential metabolites promoting regeneration, and finally found a “star molecule” uridine.Data showed that uridine had previously been used as a drug for the prevention and treatment of cardiovascular diseases and other activities.In the new paper, the researchers showed that mice treated with uridine by injection, smear or oral treatment improved the repair of five tissues and organs after injury in animal experiments.For example, mice with muscle injury enhanced limb grasping, mice with hair injury realized hair regeneration, cardiac contractility of myocardial infarction mice was enhanced, and liver fibrosis of mice was alleviated…Aged mice fed uridine directly for two months also showed significant improvement in systemic motor capacity.These studies confirmed that uridine is a key metabolite that can delay senescence of human stem cells and promote multitissue regeneration and repair in mammals.”We believe that a single metabolite uridine can promote the regenerative repair process in mammalian multi-organ tissues.”This is also supported by higher levels of uridine in the blood of young people compared with the blood of the elderly, Zhang explained.The research was funded by the Ministry of Science and Technology, the National Natural Science Foundation of China, the Chinese Academy of Sciences and the Beijing Municipal Government.Professor Guanghui Liu, Jing Qu, Institute of Zoology, Chinese Academy of Sciences, and Weiqi Zhang, Beijing Institute of Genomics, Chinese Academy of Sciences are the co-corresponding authors of this paper.Paper links: https://www.nature.com/articles/s41421-021-00361-3 source: science and technology journal editor: Liu Yiyang audit: dragon final: He Yi